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Genomics, however, does not elucidate material properties, nor the mechanistic relation of hierarchical multi-scale structures and their resulting properties.
Although this bias for retention of short introns may also be a result of selection for inclusion of short sequences, another indirect evidence that supports a possible mechanistic relation of short introns and retention is the higher frequency of shorter non-retained introns in intron retaining genes.
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Causal and mechanistic relations of molecular aberrations and gene expressions were not addressed in these studies.
Akavia et al. inferred mechanistic relations of gene expressions and phenotypes in melanoma [ 32].
The mechanistic relation, complicated because of the pleiotropic function of cytokines, between the pro-inflammatory IL-6 and organ dysfunction has recently been established in an animal model [ 7].
Specifically, we demonstrated that LM1 signalling and biomimetic extracellular elasticity are clearly necessary for functional differentiation of MECs; these cells in turn exhibit a strong correlation with biomimetic cellular elasticity, although the proof of a mechanistic relation between the latter and β-casein expression remains to be elucidated.
However, the new emphasis on mechanisms in biology and the special sciences demanded an analysis of mechanistic relations across levels of organization.
Of note, accumulating evidence suggests a mechanistic relation between the cholesterol metabolism in the brain and the formation of Aβ plaques in AD development (Martins et al., 2006).
According to the present results, there appears to be no mechanistic relation between the early and late adverse effects of radiation treatment.
The exact temporal and mechanistic relation remains unclear.
This potential mechanistic relation needs to be investigated more closely.
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