Sentence examples for mechanistic rationale for from inspiring English sources

Relevant literature was analysed to find a mechanistic rationale for the mined features, which resulted in four new structural alerts for in vitro mutagenicity.

Significant tensile stresses can be generated locally along certain directions, which offers a mechanistic rationale for the internal cracking observed experimentally.

These findings provide a mechanistic rationale for female susceptibility to AD and suggest a potential window of opportunity for AD prevention and risk reduction in women.

In addition, radical-scavenging experiments were conducted to identify the key reactive species formed in the reaction, allowing a mechanistic rationale for the superior photocatalytic activity of 2%Al-2Al-2ZnO to be proposed.

In summary, molecular profiling of chRCC identified alterations in genes and protein expression that might provide a mechanistic rationale for off-label use of approved therapies in advanced chRCC, and could guide the design of molecularly targeted clinical trials.

The residence time distribution and flow visualization measured by a high speed imaging camera provided the mechanistic rationale for the superior behavior of the reverse over the forward DME configurations and showed the dominant granulation rate processes therein.

Mechanistic rationales for hormesis also borrow from such areas as biotransformations of xenobiotics, substance interactions deemed potentially protective, and actions of essential nutrients.

These data provide mechanistic rationales for validating the chemopreventive and therapeutic efficacy of decursin and its derivatives in preclinical animal models of breast cancer.

The new method can provide mechanistic rationales for the differential and common effects of pharmaceuticals as demonstrated for three prototype cardiovascular drugs (a statin, a fibrate and an LXR activator).

Our approach provides mechanistic rationales for the differential and common effects of drugs and may help to better understand the origins of drug actions and the design of combination therapies.

Our proposed disease AOPs, like AOPs in toxicology, would describe a chain of causally linked key events causing downstream effects at several biological levels and provide clear mechanistic rationales for diagnostic, preventative, and therapeutic interventions in the era of personalized medicine.