Molecular modelling investigations provide a mechanistic rationale to the results observed.
Relevant literature was analysed to find a mechanistic rationale for the mined features, which resulted in four new structural alerts for in vitro mutagenicity.
Significant tensile stresses can be generated locally along certain directions, which offers a mechanistic rationale for the internal cracking observed experimentally.
Herein, we discuss the biological and mechanistic rationale behind combining radiation with checkpoint blockade immunotherapy, with a focus on the preclinical data supporting this potentially synergistic combination.
These findings provide a mechanistic rationale for female susceptibility to AD and suggest a potential window of opportunity for AD prevention and risk reduction in women.
While these observations may hint at which of carnosine's diverse properties are responsible for increasing chronological lifespan, any mechanistic rationale must also account for carnosine's selective toxicity towards tumour cells.
In addition, radical-scavenging experiments were conducted to identify the key reactive species formed in the reaction, allowing a mechanistic rationale for the superior photocatalytic activity of 2%Al-2Al-2ZnO to be proposed.
These events represent important pieces of a clear-cut mechanistic rationale behind the failure of the NMO-IgG binding, while the water channel function as well as the propensity to aggregate into OAPs remains unaltered.
In summary, molecular profiling of chRCC identified alterations in genes and protein expression that might provide a mechanistic rationale for off-label use of approved therapies in advanced chRCC, and could guide the design of molecularly targeted clinical trials.
The residence time distribution and flow visualization measured by a high speed imaging camera provided the mechanistic rationale for the superior behavior of the reverse over the forward DME configurations and showed the dominant granulation rate processes therein.
However, the mechanistic rationale for this dichotomy are the subject of ongoing debate.
