The understanding of the CO2-BMP mechanistic process is discussed to assist with the analysis and modelling of other gas-to-gas conversion processes.
For example, the drug bortezomib (a proteasome inhibitor used to treat multiple myeloma) is known to cause peripheral neuropathy in some patients, but the mechanistic process is still not clear (29).
Furthermore, FTI treatment ameliorates some effects of progerin, revealing mechanistic processes that are highly significant to clinical applications of FTI treatment in HGPS patients.
The general incentives to develop mechanistic models for pharmaceutical processes are listed, and our vision on how this can particularly be done for fluidized bed drying processes of wet granules is given.
Advances in the mechanistic understanding of biological processes are largely powered by innovations in tools to manipulate the biological system of study.
This approach is also known as mechanistic modeling because it describes known biological or mechanistic processes and is motivated by the observation that different molecular features can have different patterns of molecular evolution [ 20, 21, 36- 43].
2, 5 With current gene expression technologies, we can now examine many metabolic and mechanistic processes that were previously difficult to measure.
The underlying mechanistic processes may be manifold and include, among others, neofunctionalization (Boucher et al. 2014) and subfunctionalization (Chain and Evans 2006), for example, due to newly attained biochemical functions (Ganfornina and Sánchez 1999), or new genomic (Abascal et al. 2013) or cellular (Soskine and Tawfik 2010) environments.
However, these types of models, although incorporating crucial mechanistic processes, have not yet been widely applied in ecological forecasting [ 22].
However, the rationale behind these choices has not been based on a clear mechanistic process that is obvious to the reader.
