Sentence examples for mechanistic pathways such from inspiring English sources

In many cases, if we are to predict complex ecosystem responses to impacts such as species extinction or introduction, changes in disturbance regime and altered levels of limiting resources, models incorporating multiple mechanistic pathways, such as those typical of webs of interacting species, will need to be applied to data from real ecosystems.

Over the last decade, the therapeutic approach for MM has evolved and the treatment paradigm has shifted to novel drugs that target different mechanistic pathways, such as immunomodulatory drugs (thalidomide and lenalidomide) and proteasome inhibitors (e.g., bortezomib) [ 1, 7– 9].

71 One important application of new discoveries will be in the development of medications that more precisely target key mechanistic pathways, such as the RANK-ligand pathway, cathepsin K inhibition, and Wnt signaling manipulation.

The mechanistic pathways of such an association remain elusive, with intrication of inflammation, metabolism, and apoptotic phenomena.

Evidence for such mechanistic pathways exists in both the toxicology and epidemiology literature.

While such mechanistic pathways are yet to be elucidated, our findings suggest that telomere rate of change may be an important predictor of human longevity.

Finally, future research should also assess alternative mechanistic pathways besides air pollution (such as stress) for understanding the adverse health effects of wildfire events.

Such mechanistic pathways may be important in cases of altered placental angiogenesis due to obesity since cytokine balance is often affected as a consequence of overnutrition.

Although ToxCast HTS data and other information may not yet be sufficient to predict developmental toxicity in animals and humans, it is providing unique and valuable mechanistic information on prototypical toxicity pathways such as vascular disruption that could assist in chemical prioritization and further targeted testing.

Moreover, targeting such separate mechanistic pathways could be beneficial, unlike the combination of targeting IL-1 and TNFα, which has been shown to be proinfective [ 25].

Genome-wide association studies (GWASs) are an unbiased method for the discovery of new functional mechanistic pathways in disease processes [ 53] such as preterm birth and abnormal fetal growth.