Sentence examples for mechanistic overlap between from inspiring English sources

These data suggest possible mechanistic overlap between HD and disorders of primary basal ganglia copper and iron accumulation.

The increasingly apparent mechanistic overlap between neurodegenerative diseases suggested that susceptibility genes found in AD GWAS may also be relevant to prion disease.

Crucially, this suggests significant mechanistic overlap between WLDS-sensitive axon degeneration and the axon outgrowth defect in these mice.

Interestingly, TDP-43 pathology is also associated with forms of frontotemporal dementia (FTD), suggesting some mechanistic overlap between these neurodegenerative diseases.

Despite the promotion of "on pathway" aggregation by 5-HT, the occurrence of SDS-resistant oligomeric intermediates (Fig. 2C) similar to those observed for dopamine induced "off-pathway" aggregation [17,26] suggests some mechanistic overlap between these two processes.

However, the full extent of any mechanistic overlap is an interesting topic for future studies.

We also observed similar phenomena with cIAP1 overexpression as we did with XIAP, with consistent mechanistic overlaps.

Whether this difference in radiation delivery between our fly model and CRT is of sufficient mechanistic significance that there would be no overlap between the genes and signaling pathways in flies and humans that confer radioresistance remains to be determined.

Nevertheless, the mechanistic relationship between these phenotypes remains unclear, and in many cases the overlap between stress resistance and longevity is inexact.

It has been shown that there is a significant overlap between evolutionary breakpoints and fragile site locations and that, even if no mechanistic role could be demonstrated, some fragile regions of the genome may be more likely to experience reorganization [ 27].

Interestingly, despite a presumed mechanistic link between activation of growth factor receptors, MAPK signaling and cell proliferation, there was minimal overlap between genes in the reported MAPK and proliferation signatures, and no significant association was observed between the MAPK signature, age and ERBB2 positivity.