Here we use an iterative and tightly integrated experimental and modelling approach to develop, explore and validate mechanistic models of proteasomal peptide-hydrolysis dynamics.
This can be facilitated by developing mechanistic models of the multi-phase systems in the process.
Mechanistic models of explanation have become entrenched in philosophical accounts of the life sciences (Darden 2006, Craven 2007).
This paper considers the utility of statistical goodness of fit testing in the context of mechanistic models of carcinogenesis.
We propose further experiments on homotypic clusters that would be useful in developing mechanistic models of gene expression.
Mechanistic models of cell signaling networks are linked to PK/PD models of physiological processes at the level of tissues and organisms.
Recent developments in mechanistic models of roughness- and deflection-induced pavement-vehicle interaction aim at providing such engineering estimates.
From conceptual, empirical models, a move towards mechanistic models of soil formation followed at a slower pace.
Mechanistic models of within-cell signal transduction networks can explain how these networks integrate internal and external inputs to give rise to the appropriate cellular response.
The integrated findings from ecological experiments, mechanistic models of landscape dynamics, socio-economic land-use models, policy analysis and transdisciplinary stakeholder interactions are presented consecutively.
First, coalescence frequency expressions derived from mechanistic models of the relative motion of the drops are evaluated based on their ability to predict the experimental transient size spectra.
