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This model substitutes simpler, systems measures to replace the more complex, step-wise, mechanistic measures used elsewhere, [e.g. [ 13, 14]].
We have specified two primary outcomes with the other measures being either secondary outcomes or mechanistic measures which will help us understand the underlying mechanisms explaining changes in pain and function.
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The trial describes novel mechanistic outcome measures using magnetic resonance spectroscopy (MRS).
Although we argue that the Mechanistic Assessment measured participants' level of mechanistic knowledge of the robot, it is possible that the assessment's questions target a different construct.
Relevant clinical outcomes in drug-treated patients versus placebo-treated patients should be compared over at least 1 and possibly as long as 2 years with biomarkers reflective of pathogenesis and of the drug's mechanistic effects measured concurrently.
However, even if the assessment did not measure mechanistic knowledge per se, it is still measuring how participants think about the robot, suggesting that readily accessing mechanistic knowledge can influence the use of existing math knowledge.
This new approach based on measuring mechanistic indicators of release in vitro and in vivo has the potential to design better, more predictive in vitro release tests for these formulations and potentially lead to mechanism-based in vitro-in vivo correlations.
To address mechanistic questions, we measured the expression of mitochondrial proteins from this initial study.
Before considering the data obtained with the three different agonists, we will discuss the mechanistic findings from measuring membrane currents and manipulating Ca2+ entry.
Here, I present a mechanistic niche model that measures species' responses to major seasonal temperature gradients that interact with the physiology of the organism.
The mechanistic model regresses the measure of gene expression for the kth gene on the methylation measures obtained within the promoter of the kth gene.
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