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In relation to global change, responses to increased atmospheric CO2 and temperature should be modeled in a mechanistic manner.
More recently, the switch to assessing drug products in a more biorelevant and mechanistic manner has advanced the understanding of drug formulation behavior.
When considering the consumption of organic compounds due to the oxidation by Cr VI), an average rate coefficient of 9.33 (±0.65) μM−1 h−1 was determined, at pH 2. Although the function of the pH could not be expressed in a mechanistic manner, an empirical model able to describe the pH dependence was obtained.
The extension to ecological outcomes suggests that integrating the information that genomic methods afford (e.g., identifying the genes underlying a quantitative trait) can expand our understanding of evolutionary ecological dynamics in a mechanistic manner.
These findings concur with Connell's [ 29] and White's [ 15] conclusions about men's tendency to view their bodies in a mechanistic manner.
This type of intracellular PK-PD models including both target and toxicity organs provides a quantitative tool to evaluate therapeutic indices in a mechanistic manner.
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In contrast with traditional meta-analysis, this has offered the opportunity to describe processes in a mechanistic or semi-mechanistic manner (see Supplementary Data online).
It's also clear that most of them are Homme's riffs, cranked out in the terse, mechanistic "robot-rock" manner he devised for Queens of the Stone Age.
The development of a generic workflow translating genotypes to clinical incident rates in a mechanistic and quantitative manner is a fundamental extension.
The main disadvantage is that the early radiation response is typically treated in a less mechanistic, more phenomenological, manner than in the short-term models, and similarly for the dose-rate response.
To the best of our knowledge, there have been no previous attempts to employ Bayesian network analysis to unravel dynamic protein interactions based on physiological in vivo data in such a mechanistic and qualitatively validated manner (i.e. including in vivo confirmation of in silico perturbation-dependent predictions).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com