Sentence examples for mechanistic knowledge in from inspiring English sources

Against that backdrop many simple inclusions of mechanistic knowledge in fitness models appear like major advances.

Human efficacy trials are substituted with a very stringent, possibly more difficult, FDA approval pathway: the Animal Efficacy Rule, which requires a good understanding of mechanistic knowledge in two or more animal models predictive of human response [ 163].

Due to the intrinsic difficulties and ethical limitations in assessing the functional and dynamic properties of the LN compartment in course of human disease, animal models of chronic (autoimmune) arthritis represent therefore a fundamental tool to advance mechanistic knowledge in the field.

In conclusion, we recognize biological complexity and develop a novel modeling tool to integrate prior mechanistic knowledge into a mathematical model.

With the number of possible targets, greater modifications, and experience of past failures, there is hope that the mechanistic knowledge gained in the past two decades of cell death research will soon translate to success in the clinic for a wide range of diseases.

Additionally there is a dearth in mechanistic knowledge that governs alteration in metabolism of a drug by another one, in particular herbal products and few systematic reviews have been generated to help clinicians in devising better counseling strategies [37, 38, 65, 75, 81].

However, if well validated, mechanistic knowledge of PTMs in RIP140 might be exploited for therapeutic purposes by targeting upstream signalling pathways that control its activity.

Furthermore the available mechanistic knowledge (or confidence in causal pathways) is considered a basis for preventive actions, and the available evidence is considered sufficient for policy action, even if there is still a need for "action knowledge" to be further researched.

The rationale behind our modeling approach was to incorporate current mechanistic knowledge about C2 photosynthesis in Flaveria in such a way that we can answer the question: Given our current understanding of C2 photosynthesis, what is the implementation of this pathway in the plant leaf that optimizes fitness-relevant criteria?

Our results support previous findings that mechanistic knowledge can be useful in scaffolding people toward mathematical strategies.

Given the impressive progress in mechanistic knowledge of human biology and toxicology, the time is right for a conceptual approach for designing testing strategies that cover the integral mechanistic landscape of developmental neurotoxicity.