Sentence examples for mechanistic justification from inspiring English sources

Such a through-flux has earlier been postulated in the literature, but with unrealistic mechanistic justification.

However, as yet there has been no mechanistic justification for either assumption and, since quantifying fitness effects of epistatic interactions between multiple resistance or virulence genes empirically is notoriously difficult, it is not known which types of epistasis tend to naturally occur in the wild [for related discussion see 6].

(2013) may explain the recognized risk for secondary cancers in such patients following external beam radiotherapy and genotoxic chemotherapy, for which a mechanistic justification has thus far been lacking (Kleinerman et al., 2012; Wong et al., 2014).

The current study indicates that effective inhibition of the Wnt/β-catenin pathway in CRC cells expressing FAK and PYK2 will only be achieved by simultaneously targeting both kinases, which provides a solid mechanistic justification for clinical use of FAK/PYK2 dual inhibitor instead of FAK-specific inhibitor for better clinical outcomes in CRC patients.

Understanding the fundamental behaviors of organic molecules, how structure relates to reactivity, was sufficient justification for such mechanistic explorations, a testament to a time when society was more forgiving of curiosity-driven science.

In our case study, the read-across justification, first, will be based on mechanistic understanding in combination with toxicokinetic and toxicodynamic assessment; second, it will be strengthened by selected in vitro data.

Ginkgo biloba leaves have been used for many centuries in traditional Chinese medicine and justification for quercetin supplements is historical rather than mechanistic.

There is no compelling evidence-based justification for a general low-exposure linearity; rather, case-specific mechanistic arguments are needed.

Justification of a systems model on the basis of plausible structures and parameter values based on prior mechanistic knowledge and qualitative comparison of prediction vs. observations all constitute subjective criteria and should be acceptable for systems model justification.

Applications of the mechanistic niche model are scale-dependent, so both the results and discussion points below require justification in relation the spatiotemporal scale of the data.

We also found that the categories of justifications changed with age, with a move away from intuitive considerations towards mechanistic ones.