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Even when modeling leads to the characterization of particular molecule fragments related to toxicity, it is not easy to build a precise mechanistic interpretation for their role in biological activity (see for example [19]).
In addition, it could provide a mechanistic interpretation for the effector-mediated activation.
In the light of all this and of the recent evidence that Th17 cells play a role in immune-mediated control of tumors [38], [39], [40], our results may provide a mechanistic interpretation for the observed coupling of protective antitumor immunity with autoimmunity during IFN-α therapy.
Our data presented here may have provided a mechanistic interpretation for their findings.
Finding a mechanistic interpretation for these alterations is important to understand pathophysiological processes, however it is not an easy task.
Furthermore, there is no obvious mechanistic interpretation for why the inhibition strength should be different with cellobiose and pNPG or MUG.
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What are the possible mechanistic interpretations for the destabilizing event?
The influence of environmental stress on children's health can be assessed by biomonitoring studies in maternal and umbilical cord blood using validated biomarkers of exposure, early genetic effects, and genetic susceptibility, in combination with new approaches, for example, (epi genomics to facilitate mechanistic interpretations (for review, see Vineis and Perera 2007; Wild 2005).
The response features and their dependency on the rate limiting step have been rationalised in terms of conclusions, which can serve as general guidelines for mechanistic interpretation of experimental transients from hydrocarbon oxidation over metal oxides.
The utilization of molecular endpoints in ecotoxicology can provide rapid and valuable information on immediate organismal responses to chemical stressors and is increasingly used for mechanistic interpretation of effects at higher levels of biological organization.
Despite its limitations, we developed a simple, straightforward and easy-to-use tool for hypothesis building, towards a mechanistic interpretation of experiments, seeing the forest for the trees in a large amount of data.
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