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Our structural data are consistent with this concept and offer a plausible mechanistic interpretation based on several observations.
Analysis of other genetic risk factors, epigenetic markers, and other modulatory influences will require validated clinical and molecular phenotyping based on disease-linked attributes and mechanistic interpretation based on detailed understanding of the underlying pathobiology.
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As an approach to achieving this goal, mechanistic interpretations based upon gene expression changes that are determinants of adverse toxicological outcomes were applied to the analysis of low-dose gene expression profiles.
Another important type of modelling is known as reversed-engineering, in which parameters with mechanistic interpretation are estimated based on the data, and where conclusions can be drawn regarding mechanisms in the biological system [ 6– 9] (Fig. 1 d).
Heart rate (fH), ventilation rate (fA), and oxygen consumption rate were additionally monitored as diagnostic indicators for the mechanistic interpretation of acid-base disturbances.
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Palaeoclimatic interpretations based on Artemisia s.l.l
The aim of this work was to extend the current comparison based knowledge towards a mechanistic interpretation of the high temperature erosion of Cr3C2 based thermal spray coatings.
The approach was chosen because it could rapidly obtain a complete set of estimates based on a mechanistic interpretation and do so with more accuracy than alternative approaches.
A detailed (expert) analysis at the last stage of regulon reconstruction includes mechanistic interpretation, prediction of possible effectors of TFs (based on regulated metabolic pathways), and a tentative functional assignment of previously uncharacterized genes.
These results show that caution is needed where a mechanistic interpretation of polymer binding is derived from interpreting LTSEM images.
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