The wide range of published PPI IC50 values for microsomal H,K-ATPase reflects the mechanistic necessity for compound acidification to allow formation of a thiol-reactive sulfoxide intermediate which then irreversibly derivatizes H,K-ATPase α subunit cysteine residues leading to enzyme inhibition.
To simulate snow cover, the mechanistic intermediate-complexity snow scheme (ISBA-ES; Boone and Etchevers [42] has been implemented in ORCHIDEE-GM v2.2 (updated with ORCHIDEE Trunk.rev3623), which improves the representation of snow processes such as snowmelt timing [43]. 3.
Early mechanistic endpoints, which can serve as intermediate outcome markers in TBI trials, are still lacking.
The photosynthesis process is modeled using a precise mechanistic approach which is applicable to the commonly planted C3 species.
The authors advance a mechanistic hypothesis in which excess base would form an N-fluoroammonium KCO3– salt intermediate, in which the KCO3– triggers fluorodesilylation of the substrate and would be followed by the enantioselective transfer of fluorine to the substrate.
In this investigation, the mechanistic models were proposed using reaction pathways that are defined by the most abundant reactive intermediates (MARI) which are converted into products through surface reaction over the one or more catalyst active sites [6, 23, 24, 25].
Or was it a period of Darwinian brutality and mechanistic thinking, to which Renaissance humanism finally, mercifully, put an end?
Our results support a mechanistic model in which the collagen triple helix unwinds prior to proteolysis.
Given these electrotactic responses, we next investigated possible mechanistic pathways by which U87 or DAOY cells respond to electric fields.
The mechanistic details by which DAP5-eIF3d and eIF4E-eIF4GI mRNA selectivity are determined are not yet understood.
