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In cases in which the detailed structure of the network does not permit the transfer of complete formalisms between disciplines, comparison of mechanistic interactions in systems for which we have significant day-to-day experience can provide analogies for interpreting relatively more abstruse biological networks.
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The molecular level mechanistic interactions captured in AlzPathway, together with a community-driven, web based curation platform, would provide a comprehensive resource to the AD community towards deeper insights into AD pathogenesis and identification of novel therapeutic targets.
Descartes radically reconceptualized the problem by his dualism of matter and mind; life was a problem for which an explanation was to be sought in the mechanistic interactions of matter, and there was the question of how mind was related to the matter in living beings.
An integrative systems biology approach is needed to understand the behaviour of all biological components in a system, particularly their mechanistic interactions.
This review discusses the mechanistic interaction between predisposing factors, alterations in intracellular signalling, and the electrophysiological mechanisms of POAF.
Therefore, we tested a potential mechanistic interaction between Chop and T-bet in CD8+ T cells.
Additional investigations are necessary to understand the specific mechanistic interaction of TNF-α and Notch3 signaling in response to ozone.
This review discusses the mechanistic interaction between predisposing factors and the electrophysiological mechanisms resulting in POAF and their therapeutic implications.
Yet, its mechanistic interaction with oncogenic signaling remains elusive.
10.7554/eLife.02478.014 Figure 5. Mechanistic interaction between C2 and C4 cycle.
The relationship between mechanistic allelic interaction in multi-gene systems and genetic contribution to population variance remains poorly understood.
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