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General mechanistic implications for de novo induced catalysis are presented.
We propose a model of proteolytic reciprocal negative regulation with mechanistic implications for the combined clinical use of proteasome inhibitors and proapoptotic drugs.
This review will summarize the recent findings on 26S proteasome structure and discuss the mechanistic implications for substrate binding, deubiquitination, unfolding, and degradation.
Together these results provide greater insight into the interrelationship of the factors underlying multisensory integration in SC neurons, and may have important mechanistic implications for multisensory integration and the role it plays in shaping SC-mediated behaviors.
Our results have also important mechanistic implications for the initial steps of the pathogenic conversion process.
Understanding how androgen receptor (AR) function is modulated by exposure to steroids, growth factors or small molecules can have important mechanistic implications for AR-related disease therapies (e.g., prostate cancer, androgen insensitivity syndrome, AIS), and in the analysis of environmental endocrine disruptors.
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We present quantitative kinetic information regarding the rates of residue accumulation and CO2 production; we also briefly discuss the over-all mechanistic implications of our results for methanol electrocatalysis on Pt(111).
Mechanistic implications of this work for lung cancer included that more than one of the stages of lung carcinogenesis was strongly affected by smoking [ 9, 10].
These methodologies will provide a better understanding of the mechanistic implications of utilization of Adipogel for hepatocyte functional augmentation.
The mechanical and mechanistic implications of dwell time, the feasibility for inferring sustained-load crack growth rates from the dwell time tests, and the usefulness of the superposition model for life-cycle design and management of engineered structures are discussed.
The mechanistic implications of these findings are also relevant for conditions with secondary mitochondrial dysfunction, including aging.
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