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Indeed, several of his findings have been translated into clinical studies, including an innovative N-of-1 study at Columbia in which master regulators are identified and pharmacologically targeted on an individual patient basis in several aggressive malignancies, thus getting a step closer to deliver on the promise of a truly mechanistic implementation of precision medicine.
Indeed, several of his findings have been translated into clinical studies, including an innovative N-of-1 study at Columbia in which master regulators are identified and pharmacologically targeted on an individual patient basis in 14 aggressive malignancies, thus getting a step closer to deliver on the promise of a truly mechanistic implementation of precision medicine.
Furthermore, at the level of mechanistic implementation, a biophysically based neural model grounded in reinforcement learning was also shown to reproduce matching behavior in a baiting task.
In all organisms, the informational and catalytic entities in the genome are well-separated into respectively dsDNA and ssRNA, and can therefore be seen as the mechanistic implementation of these functional modules.
It is clear that the distinct system responses are critical for the proper functioning of the DARPP-32 signaling network, and that a better elucidation of their mechanistic implementation and robustness could possibly help deepen our understanding of its functioning, identify weak points in the system that are associated with disease outcomes, and provide targets for therapeutic interventions.
The significant gains following BrainU 202 and 303 in the intellectual environment of the classroom demonstrate that professional development hours beyond the first year were critical to moving beyond "mechanistic" implementation of classroom activities to a more intellectual climate around scientific investigations.
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Below we propose specific examples of potential mechanistic implementations in both unicellular and multicellular organisms.
Milkowski sketches a mechanistic theory of implementation of computation against a background of extant conceptions, describing four dissimilar computational models of cognition.
The combined approach of mechanistic and clinical implementation studies is expected to lead toward more specific and evidence-based exercise prescription guidelines that can optimize long-term therapeutic outcome at an affordable socio-economic cost price.
This paper demonstrates how pre-computed rate data can be used to enable the numerically efficient implementation of mechanistic kinetics in a reactor model for an automotive ammonia slip catalyst.
In this context, an automated implementation of mechanistic models (simulating and visualizing crystal growth under different environmental parameters) could eliminate this barrier to entry and promote widespread adoption to propel design of crystalline-based products into the next generation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com