Sentence examples for mechanistic impact from inspiring English sources
This information might have a critical mechanistic impact for PD pharmacotherapeutic design.
For example, a number of candidate genes have been associated with irritable bowel syndrome, but little research has examined the mechanistic impact on epigenetics [ 4].
In this review, we take an effort to bring together the highlights of sirtuin research in order to shed some light on the mechanistic impact that sirtuins have on the pathogenesis of cellular malignancy.
Although the c.1146A>G variant could be an important clue in understanding why some patients are more severely neurologically affected, the mechanistic impact of bi-allelic OPA1 mutations in the emergence of syndromic DOA+ phenotypes needs further consideration.
For example, incorporating the capability to predict the mechanistic impact of additional cellular processes, such as signaling and transcriptional regulation, at the genome scale in human tissues presents additional, significant challenges.
Because, synchronous activity determines synaptic gain [ 7], oscillations have a mechanistic impact on neuronal processing rather than being epiphenomenal which completes the circular causality between synchrony and synaptic efficacy.
Mechanistic impacts of oxygen reaction space limited to the liquid film are discussed.
The mechanistic impacts of angiogenesis, lymphangiogenesis, autocrine versus paracrine pathways as well as the relevance of constitutively activated receptors have to be further clarified.
Our results show that the precise residues at which charge accumulates have distinct mechanistic impacts on the desensitization process further supporting the idea that specific residues and their phosphorylation are required.
The accuracy of the computational methodologies applied here shows a potential for their wider application in studies of drug binding and in assessments of functional and mechanistic impacts of mutations, thus assisting efforts in precision medicine.
Together with the enhanced sampling (Fig. 3), this methodology shows potential for wider application in studies of drug binding and in assessments of functional and mechanistic impacts of disease mutations.
