Sentence examples for mechanistic hypothesis of from inspiring English sources
One mechanistic hypothesis of anthracycline-induced cardiotoxicity (ACIC) relates to oxidative damage and mitochondrial dysfunction, which leads to cardiomyocyte apoptosis (Fig. 1).
We integrate signalosome components, deduced from genome- and proteome-wide arrays and candidate analyses, to propose a mechanistic hypothesis of how cannabis-induced ectopic cannabinoid receptor activity overrides physiological neurodevelopmental endocannabinoid signals, affecting the timely formation of synapses.
A thorough mechanistic hypothesis of autism via genetic risk and oxidative stress has been described by Deth et al. (2008).
The mechanistic hypothesis of VLX40 causing tubulin inhibition was subsequently confirmed by measuring tubulin polymerization in vitro.
Basic recognition of the chemistry of toxicant target reactions has led the development and testing of a rational mechanistic hypothesis of ACR neurotoxicity (see below).
It is apparent that we currently lack a clear mechanistic hypothesis of how peroxiredoxins might generate self-sustaining rhythms from which circadian signals emanate.
A mechanistic hypothesis on the elevated expression of MaoB [ 42], Tm1 [ 72], and BACE1 [ 25] is a deregulated one-carbon metabolism which leads to reduced promoter methylation and, consequently, to increased protein expression.
Thus, we are able to generate testable mechanistic hypotheses of the molecular changes that drive disease risk.
These models include dose-dependent mechanistic hypotheses of toxicological interactions which can be tested by model-directed experimental design and used to identify dose regions where interactions are not significant.
Therefore, beyond enhancing power for association analysis, intermediate phenotypes hold the additional promise of testing mechanistic hypotheses of gene action.
These results provide biological information useful for articulating mechanistic hypotheses of exposure to xenobiotic mixtures and physiological responses.
