Consistent associations between HLA alleles and disease outcomes suggest an underlying mechanistic function, and prompted us to question whether the scope of the epitope repertoire contributes to the composite effectiveness of the CTL response.
This phenomenon may be based on variable degrees in similarity concerning primary sequence, solution structure, conformational dynamics, mechanistic function and antifungal spectrum [1 5].
Those of us maternal bodies are at risk of being commodified and diminished, having our bodily realities reduced to mechanistic functions and our lived experience disregarded.
Briefly, the CKDGen consortium has identified various genes associated with CKD and kidney function, of which the mechanistic function of UMOD and SHROOM3 has been studied in the greatest detail, which will be discussed in the following section.
While we fully accept that we cannot exclude indirect effects of REV1 deficiency, addressing the details and mechanistic function for REV1 in kataegis is beyond the scope of this paper, and will require extensive additional work.
The flavivirus nonstructural glycoprotein NS1 is an enigmatic protein whose structure and mechanistic function have remained somewhat elusive ever since it was first reported in 1970 as a viral antigen circulating in the sera of dengue-infected patients.
Whilst such indices give a simplified index of the 2-dimensional structure of a compound they also have a direct relationship to reactivity and along with atomic and group-based descriptors (also used in our models), some link to mechanistic function can be inferred, and their utility has been well described in the literature [8].
The flavivirus nonstructural glycoprotein NS1 is a cell surface protein (soluble entity) that generates neurovirulence in host neural cells after peripheral inoculation of virus, a multifunctional protein that shows mechanistic function [ 115] and assists the virus in neuronal invasion [ 116].
Despite an increasing number of studies on the biogenesis and mechanisms of miR-22 in the pathogenesis of GC, the accurate expression and mechanistic function of them in GC remain elusive.
When I speak about "mind" here, I am using the more pejorative view of it that is often implied when we are talking about disciplining ourselves not to give into its unconscious, ego-driven, mechanistic functioning -- and I am speaking about it as differentiated from the "brain".
In contrast, the esterification of the PTS1-receptor seems to have a physiologically relevant mechanistic function, because it is required for the recycling and reuse of Pex5p for further rounds of matrix protein import.
