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Participant characteristics from case report forms need to be integrated with molecular characteristics from mechanistic experiments on procured specimens.
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In the present study, mechanistic experiments focussing on the mode of HIF-1 inhibition by chetomin, in particular its interaction with p300, as presented by Kung et al. [ 13] were not performed.
The reviewers agreed that further insight into the mechanism of action was not needed for a Short Report, but there was consensus on requiring validation of key mechanistic experiments in a second cell line.
Recent mechanistic experiments in mice examined oxidative stress and, specifically, effects on lipid-peroxidation derived alipid-peroxidation derivedtoimmune disealdehydes
These experiments were also undertaken to conduct mechanistic experiments, some of which required diaphragm muscles to be used immediately on dissection.
Further mechanistic experiments with K. oxytoca excluded different microbial factors and hypothesized that quorum sensing molecules might play a role in the inter-kingdom signalling during wound healing.
Mechanistic experiments indicate that these cyclisations are not metal-catalysed.
Further mechanistic experiments are needed to explain the exact role of anti-TNF in SS.
However, limited numbers of mechanistic experiments can be performed with human tissues and cells.
MH designed the study, performed mechanistic experiments and coordination and finalized the manuscript.
Therefore, we chose the doses of 20 μM of Med with 2.5 ng/ml of TRAIL for further mechanistic experiments.
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