The provided mechanistic examples (e.g. MGEs, exosomes and symbiotic microorganisms) are also not the subject.
Mechanistic examples of site-specific O-GlcNAc regulatory function are limited, but include influences on protein protein interactions, subcellular localization, protein half-life, and interplay with phosphorylation (Kamemura and Hart, 2003).
It serves as a mechanistic example of how a weakly bound adhesion molecule works in signaling.
Two possible scenarios (of several possible ones) include a switch in protein function and tipping a balance between co-existing beneficial and detrimental contributions; neither could be evaluated without a mechanistic example of antagonistic pleiotropy.
In a recent example, a mechanistic model was applied to predict systemic exposure following inhaled administration of SGRM in healthy volunteers using six different devices and formulation.
The current manuscript intends to demonstrate practical applications for the mechanistic model, using some case studies as examples.
For example, a reduced mechanistic model, such as the Michaelis-Menten rate law, is often proposed to fit the experimental data, at the cost of sacrificing the original mechanistic interpretation.
35 Null randomised trials have led to revisions in the causal and mechanistic hypotheses for example, the finding that positive inotropic agents do not prolong life in heart failure, refocused attention away from a mainly haemodynamic model of heart failure.
The model can fit data under various mechanistic assumptions, for example, whether transcriptional repressors work over long or short distances, whether cooperativity (direct or indirect, homotypic or heterotypic) exists between CRM-bound TF molecules, etc.
However, both inactivity and exercise have direct effects on the vasculature and specific mechanistic pathways, for example those associated with shear stress and pulse pressure, have been identified which provide a basis for direct vascular conditioning and deconditioning effects of exercise and inactivity, respectively.
For example, Engel et al (2004) provide a detailed mechanistic granulopoiesis model to account for the short- and long-term effects of combined chemotherapy and G-CSF.
