Sentence examples for mechanistic evaluation of from inspiring English sources

Heslop, J. A. et al. Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile.

To bolster the sensitivity of this system for detecting mutagenesis of weak mutagens like PQ, and to provide a tool for mechanistic evaluation of the mutagenic process, we constructed a new AS52-derived cell line defective for 8OG DNA repair.

Herein we describe the synthesis and in vitro mechanistic evaluation of novel N'-benzylidene-carbohydrazide-1H-pyrazolo[3,4-b]pyridines (3-22) designed as non-anionic antiplatelet agents and presenting a 30-fold increase in potency compared to aspirin.

The aim of this work was to investigate the mechanistic evaluation of physicochemical properties of new engineered lactose on aerosolisation performance of salbutamol sulphate (SS) delivered from dry powder inhaler (DPI).

Joinpoint regression is particularly appropriate in studying MV fatality trends because it allows for a mechanistic evaluation of changes in long-term trends that may have been affected by numerous complementary or competing factors as detailed earlier.

The focus of a majority of my work in breast cancer has been the mechanistic evaluation of methods to target ER activity in this setting of resistance, either through the development of improved receptor antagonists or through the identification of targets downstream of, or impinging upon, ER activity that can serve as secondary targets in this setting.

Knowledge of the origins of the various fluorescence parameters described in this chapter allows sensitive and informative assays to be designed, which can be used in detailed mechanistic evaluations of interactions at equilibrium, as well as the kinetics of enzyme catalyzed processes.

Moreover, animal models are useful not only for preclinical screening tool but also for later mechanistic evaluations of finding obtained in human studies.

The outcomes of the mechanistic evaluation will include regression of retinal NV at 12 and 52 weeks in terms of decimal disc area units; change in retinal vessel calibre and oxygen saturation and change in quantifiable areas of retinal non-perfusion.

Small-molecule chemical tools56 can substantially enhance biological validation and mechanistic evaluation, and in particular aid the understanding of the specific functional role of a protein in cancer.

Subsequent to assay development and high-throughput screening, my group is then required to characterise any compounds which prove active against the target of interest, through mechanistic evaluation such as steady-state and pre-steady-state experiments, or functional cell-based follow-up assays.