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The mechanistic effects of MEKi on genes encoding cartilage matrix proteins and catabolic enzymes were examined in articular chondrocyte cultures.
However, we lack an understanding of both the specific alterations in bone quality n steroid-induced osteoporosis as well as the mechanistic effects of these changes.
The analysis of grain boundary carbon segregation – barely achievable by electron microscopy – opens the possibility of understanding the mechanistic effects of dopants on mechanical properties, fracture and wear properties of bulk oxides.
These results increase understanding of mechanistic effects of Na on NO reduction over FeOx/CeO2 catalysts and serve to guide future design of oxide-based emission control catalysts that are free of Pt-group metals.
These findings unravel a more complex picture of the mechanistic effects of cilengitide on endothelial cells and, more generally, highlight the role of integrins and integrin-induced signaling events in the regulation of endothelial cell functions (See Figure 9 for a working model).
In addition, we analysed tumour tissue to determine the mechanistic effects of these combinations.
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Importantly, the representation of relative value was most pronounced at the start of the motion epoch, consistent with a mechanistic effect of biasing the starting point of the motion integration process (see below).
To test this hypothesis and further understand the mechanistic effect of spaceflight on bacterial virulence, we performed analyses on Salmonella cultured in varying media conditions aboard Space Shuttle missions STS-115 and STS-123.
To the best of our knowledge the only mechanistic effect of PrP polymorphisms in the N-terminal signal peptide (described by Stewart et al for PrP L9R) is to alter the formation of the topological form called Ctm PrP [24], and interestingly this form involves embedding of the central hydrophobic tract into the plasma membrane.
These results confirm the mechanistic effect of the P-gp efflux pump on intestinal absorption.
However, the mechanistic effect of stabilizing the CH domain remains unclear.
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