The mechanistic effects of MEKi on genes encoding cartilage matrix proteins and catabolic enzymes were examined in articular chondrocyte cultures.
However, despite the high medical relevance of this signaling pathway, the mechanistic effects on intercellular contacts on the ultrastructural level are largely unknown.
Blockade of the IL-1β pathway is therapeutically efficacious in type 2 diabetes, but the mechanistic effects on the immune system are incompletely understood.
However, we lack an understanding of both the specific alterations in bone quality n steroid-induced osteoporosis as well as the mechanistic effects of these changes.
It was found that literature data often misses important information and/or the required accuracy for resolution of the underlying mechanistic effects, especially when modelling reactor dependent variables.
The mechanistic effects on cell cycle progression and induction of apoptosis in MCF-7 cells were determined for compound 3a due to its potent and selective cytotoxic effects in addition to its promising tubulin polymerization inhibition potency.
The reaction pathways in AQ-SS processes depend not only on thermodynamic factors but also on kinetic and mechanistic effects, which operate at different scales in space and time.
In addition, the mechanistic effects on the architecture of the vessel wall and the plaque itself have been found to reduce the likelihood of significant dissection following cryoplasty as compared with those expected with percutaneous transluminal angioplasty.
In virtue of its promising cytotoxic and p38α MAP kinase inhibition potency, the furochromone derivative IXb was selected as a representative example to investigate its mechanistic effects on cell cycle progression and induction of apoptosis in MCF-7 cell lines.
This supports the hypothesis that deviations from Mendelian expectations are due to fitness effects rather than mechanistic effects such as meiotic drive due to chromosomal inversions.
While available data in the literature focus on female-mediated reproductive inhibition measured as reduced fecundity, studies of fecundity may miss mechanistic effects in both males and females.
