Sentence examples for mechanistic effect on from inspiring English sources

These data, taken together lend strong support to the hypothesis that there is an isoform specific mechanistic effect on plaque deposition and clearance that is implicated in the positive correlation between ApoE4 dose and plaque density [13], [14] and strengthens the case for therapeutic intervention targeted at ApoE4's unique tertiary structure [43].

Particular DNA mutations and their mechanistic effect on the timing, level, or quality of gene expression produce the risk of disease.

These experiments indicated the importance of integrin α5 for the channel opening; however, the shear stress-induced mechanistic effect on integrin α5 that facilitated the opening of the hemichannels was not yet clear.

It must be kept in mind that polymorphisms may only be the reflect of unidentified variations, occurring at a distance from the SNP studied, and playing the actual mechanistic effect on the cellular properties observed.

To test this hypothesis and further understand the mechanistic effect of spaceflight on bacterial virulence, we performed analyses on Salmonella cultured in varying media conditions aboard Space Shuttle missions STS-115 and STS-123.

This and other studies have addressed the physiological importance of Nanos3 in PGC development for most species; however, accurate information from a primate model may help to elucidate the specific mechanistic effect of Nanos3 on human fertility.

This study focused on the mechanistic effect of biogenic calcium carbonate nanocrystals derived from cockle shells on two different osteoblast cell lines.

In this study, blood flow occlusion was used as means to understand the mechanistic effect of circulating blood flow on post-warm-up Tmvl decline, rather than a proposed tool to maintain Tmvl during a period of inactivity.

A large multicenter randomized control trial is required to determine the efficacy and to shed insights on the underlying mechanistic effect of this intervention before it can be used routinely for septic shock patients.

These results confirm the mechanistic effect of the P-gp efflux pump on intestinal absorption.

However, despite the high medical relevance of this signaling pathway, the mechanistic effects on intercellular contacts on the ultrastructural level are largely unknown.