Gene expression of apoptosis, cell cycle, and repair genes were consistent with mechanistic dynamics described by the model.
The predictive power of different theories was also evaluated against the experimental results, providing a mechanistic interpretation of the dynamics of the in vitro oral phase of swallowing.
We further evaluate the proposed in silico model by exploring the possibility of a mechanistic maladaption in the dynamics of the regulatory NFkB signaling module.
We next attempted to leverage the insights gained from statistical analyses into mechanistic insights regarding the dynamics of inflammation following T/HS.
It also promises to provide mechanistic insight into the development of the song circuitry, in the same way that the study of song spectrograms has provided mechanistic insight into the dynamics of the peripheral apparatus that produces song [8], [9].
We also anticipate that further mechanistic studies of the dynamics of the cardiac pumping and the fluid dynamics of hemolymph contributes to the advancement of our understanding of the design of biological structure and function, and may also potentially provide important information for engineering the cardiac devices in the future.
We suggest that data at the mRNA and protein levels, combined with data-driven methods such as those described in this study, may facilitate further mechanistic modeling of the dynamics of acute inflammation as well as driving clinically-relevant advances [31], [32], [33].
First, QTL data would provide a mechanistic basis for the dynamics of phenotypic evolution uncovered by phylogenetic comparative approaches.
Further, as above, our intent in these experiments was not to develop a mechanistic model of the dynamics of the system.
We describe these in detail, and illustrate the usefulness of our classification scheme by providing a number of examples that demonstrate how it can be employed to gain specific mechanistic insights into the dynamics of gene regulation.
