Sentence examples for mechanistic driver from inspiring English sources
A phenotypic driver is usually also a mechanistic driver, since it may affect clinical phenotypes by altering the regulatory programs in cancer cells.
Conversely, a mechanistic driver may not be a phenotypic driver if the altered passenger genes do not pertain to the clinical phenotypes.
Further studies need to be performed to separate the effects of over-expression and translocation to determine the most likely mechanistic driver for decreased cell strength.
It is well established that CR increases lifespan and healthspan in a range of organisms (Anderson & Weindruch, 2010), although the mechanistic driver of these effects is currently unknown.
While network data usually constitute only static network maps, integrating them with time course gene expression information can provide clues to the dynamic features of these networks and unravel the mechanistic driver genes characterizing cellular responses.
Although our data are correlative, we conclude that intrinsic BMR phenotypes are the mechanistic driver of the contrasting landscape patterns, because the capacity to tolerate warmer environments must have largely preceded their widespread colonization and occupation (Janzen 1967; Huey & Kingsolver 1993; Gilchrist 1995).
Identification of the mechanistic drivers contributing to spatial heterogeneity in Δ13C provides an opportunity to select seed sources better suited to optimize long-term survival, vigor and cone production.
The methods we utilized can be separated into two broad categories: analyses that attempt to discern differences across the experimental procedures (ST vs. ST + HS), and analyses that attempt to define mechanistic drivers within ST or ST + HS.
Curiously, these mechanistic drivers were also phenotypic drivers, as their knock-downs abrogated tumor cell proliferation.
Different systems may have different mechanistic drivers that create, constrain, and adapt this variability.
This can also provide the distinct possibility of unraveling the mechanistic drivers characterizing cellular responses [ 6].
