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A mechanistic discussion highlights the similarities and differences between these systems and examines the interplay between reversible termination and degenerative transfer OMRP and competing 1-electron redox processes.
Detailed structure studies of uniporters may provide information on the mechanism of substrate binding-mediated reduction of ∆G ‡, as exemplified in mechanistic discussion on GLUT1 crystal structure (Deng et al. 2014).
Similarly for the mechanistic discussion based on the structure; it has to be clearly stated that the proposed mechanism is speculative.
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The chapter presents the sleep architecture and phylogeny/ontogeny so as to provide a basis for the later mechanistic discussions.
In order to set the scene for mechanistic discussions of the connections among alterations to subcellular structures, attendant changes in cell deformability, cytoadherence, migration, invasion and tumor metastasis, a survey is presented of the various quantitative mechanical and physical assays to extract the elastic and viscoelastic deformability of cancer cells.
The terminological distinction between gold(I) carbenes and carbenoids is also useful in the context of mechanistic discussions.
As will be seen below, the evidence from animal and clinical studies for insulin being a causative factor in human malignancy is weak, so the mechanistic discussions that follow currently have limited clinical relevance.
Interestingly, there was a significant overlap in the distribution of these cell-cycle proteins between grades (e.g., Aurora A and Plk1 levels, Supplementary Figure 2), which has important implications for exploitation of these molecules as predictors of therapeutic response to cell-cycle-phase-specific mechanistic agents (see Discussion).
With one foot still firmly on consecrated ground (and with Galileo's difficulties with the Inquisition very much in mind), he sought to give a materialistic, even mechanistic, dimension to the discussion.
(For further discussion of mechanistic emergence in relationship to other varieties, see Richardson and Stephan 2007).
This discussion includes mechanistic explanations for several clinically important, but poorly understood phenomena.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com