In consequence, several research groups have resorted to the deliberate addition of a soluble source of fluoride ion under stoichiometric conditions to stabilise the equilibrium between the carbene intermediate and the desired reagent, thus adding further indirect proof of the mechanistic difficulties [ 34, 35].
The absence of confirmatory evidence for many proposed exogenous model cooled down symbiotic enthusiasm, and prompted researchers to envision alternative, endogenous scenarios (Fig. 1 and Table 1), with no fewer mechanistic and conceptual difficulties.
To gain a better understanding of these reactions and overcome the difficulties, detailed mechanistic investigations are important.
In order to overcome the difficulty in developing mechanistic models for batch processes, stacked neural network models are developed from process operational data.
A secondary goal of this study is to compare the functional aspect of the middle meningeal artery (MMA) between the species because rat is often used in mechanistic studies due to the difficulty in obtaining human tissue samples.
To overcome this difficulty, the approximated mechanistic equations characterizing these immeasurable state variables could be incorporated into the NNRF model to form the hybrid neural-network rate-function model.
However, the difficulty in performing mechanistic follow-up studies has left the role of ECM remodelling in IBD uncharted territory.
Integral membrane proteins (IMPs) control the flow of information and nutrients across cell membranes, yet IMP mechanistic studies are hindered by difficulties in expression.
To illustrate the difficulty in drawing conclusions from mechanistic data, plausible-sounding mechanistic conclusions had been made simultaneously that 1,3-butadiene both is (Melnick and Kohn 1995) and is not (Bond et al. 1995) carcinogenic to humans.
They are: (1) explaining and justifying the sense in which substantial forms have causal or explanatory power, especially in the light of a developed mechanistic chemistry or physics; (2) the difficulty in understanding the relation of substantial form to properties, especially those in terms of which a given substance is defined.
