Sentence examples for mechanistic data support from inspiring English sources

For example, strong mechanistic data support tributyltin as a developmental obesogen, especially for its action through nuclear receptor signaling.

Again, there is no high-level evidence in managing this population, but anecdotal and mechanistic data support the addition of perception modulators.

The pesticide breakout group concluded the epidemiological, animal, and mechanistic data support the biological plausibility that exposure to multiple classes of pesticides may affect risk factors for diabetes and obesity, although many significant data gaps remain.

Moreover, mechanistic data support the possibility that multiple modes of action with different targets within the developing heart may be operant in eliciting cardiac malformations, consistent with the reported association between TCE and overall cardiac malformations in the absence of a strong association with any particular type of defect.

Despite the limited mechanistic data supporting this chemical induction method, it is still widely used by a considerable number of researchers [3], [5], [8], [28] [30].

Secondly, this study provides mechanistic data supporting a role for MHC isoform switching and altered calcium handling as a basis for the observed susceptibility to pump dysfunction in LCR rats.

Our review of the mechanistic data supported a threshold-based mechanism as the most plausible.

Mechanistic data supporting early-life susceptibility to DNA damaging mutagenic chemicals include increased formation of DNA adducts after exposure to vinyl chloride (Laib et al. 1989; Morinello et al. 2002a, 2002b), increased induction of micronuclei in fetal tissues (Hayashi et al. 2000), and increased mutations in brains of transgenic mice exposed to ethylnitrosourea (ENU; Slikker et al. 2004).

We focus on several key aspects in prebiotic research in relation to MetS and provide mechanistic data that support the use of prebiotic fibers in order to alter the gut microbiota composition and SCFA profiles.

Mechanistic data to support health claims is often generated using rodent models, and the influence of prebiotic supplementation has largely been evaluated using male rodents.

This provides the first mechanistic data in support of recent human cohort studies that identify an inverse relationship between vitamin B12 status and a phenotype of adiposity, gestational diabetes, T2D, and insulin resistance [ 17, 18].