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Given the complex role of the large TS domain on the one hand and the scarce structural and mechanistic data on the other hand, our identification of a well defined UIM provides a concrete basis for functional insights.
Despite not seeing a significant improvement in drug release properties, our systematic preparation of calcium polyphosphate from aqueous sodium polyphosphate solutions yielded valuable mechanistic data on this interesting fabrication strategy.
Moreover, the structural and mechanistic data on NLR proteins is scarce and mainly limited to single effector domains.
Although there is no mechanistic data on the association of these non-coding SNPs with disease, it is likely that these silent polymorphisms are associated with transcriptional control of gene expression [48].
We have now provided further mechanistic data on the action of AA.
Mechanistic data on the influence of bile acids on glucose metabolism have been mounting.
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Thus, it promotes an evidence-based approach for using mechanistic data to reduce reliance on default assumptions, to quantify variability, and to better characterize biological thresholds.
Extensive mechanistic data exists on donor specific tolerance [11], [14] where adoptive transfer of ex vivo generated host Treg cells prevents allograft rejection [22], [23].
Early guidance for evaluating mechanistic data focused on the question of whether the available studies support a hypothesized sequence of precursor events [International Programme for Chemical Safety (IPCS) 1999; U.S. EPA 1999].
Though the fear extinction data do represent a departure from the mechanistic data focusing on time points close to the stressor, we feel that including these data, and in particular the new neuron activation findings, are important to the behavioral relevance of the rest of the manuscript.
Zhang Poorman analysis provides orthogonal mechanistic data based solely on enzyme kinetics, complementing our NMR-based assays.
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