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"The most appropriate and scientifically based evaluation of the cancers reported in humans and laboratory animals as well as supportive mechanistic data is that glyphosate is a probable human carcinogen," the report states.
The schedule of events which includes completion of study questionnaires and collection of mechanistic data is described in figure 1.
One of the most challenging determinations in evaluating mechanistic data is whether an identified MOA is the cause of cancer (or another adverse health outcome).
The scientific support for this conclusion, however, can be questioned if a thorough review of the remaining epidemiology and mechanistic data is included.
Although the report did not include any linking of the imaging by ultrasound to the biochemical alterations in skeletal muscle, which reflects the mechanisms behind the rather aggressive muscle depletion often seen in critical illness, the effort to present measurements obtainable on an everyday clinical basis to underlying mechanistic data is a conceptual breakthrough.
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In like fashion, regulators and risk assessors can be better equipped to apply mechanistic data if the concepts underlying mechanistic research and the limitations that must be placed on interpretation of mechanistic data are understood.
We have also started adding small molecules to the PluriNetWork (data not shown), as stimulators or inhibitors of specific genes/proteins, wherever such mechanistic data are available.
To sum up, the phenotype of the Cry2 knockout mice together with mechanistic data are in line with the finding in this report suggesting that CRY2 has a role in winter depression.
Until more mechanistic data are available, we believe the second, noncausal explanation is more appropriate.
In addition, new criteria allowing broader consideration of mechanistic data were added to the ROC.
Also, as there is scientific disagreement over the mechanism of OTA-induced renal tumors, mechanistic data were revisited.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com