Sentence examples for mechanistic data in from inspiring English sources
The intrinsic drug resistance of high grade gliomas represents a major challenge in the clinical management of children with the disease, and efforts to understand and overcome this are hampered by a lack of mechanistic data in paediatric glioma models.
This article provides comments on the use of mechanistic data in the risk assessment process and suggestions for increasing the successful development and use of mechanistic data in risk assessments conducted in the future.
For interventional and mechanistic data, in vivo animal studies will be heavily favored because lab animals can be selected for minimal genetic variation and shorter life spans.
Other relevant data could include, but are not limited to, mechanistic data, in vitro data, or data based on upstream indicators of a health effect.
This evidence, put together, supports the approach taken by IARC to consider the animal and mechanistic data in the evaluation of carcinogenicity of these compounds in humans.
This account is supported by a large body of hematotoxicity studies (in animals and humans); toxicokinetic, genotoxocity, and mechanistic data in animals, humans, and in vitro; and a large body of null epidemiology findings.
In like fashion, regulators and risk assessors can be better equipped to apply mechanistic data if the concepts underlying mechanistic research and the limitations that must be placed on interpretation of mechanistic data are understood.
In the future one could imagine linking the functional disturbance of substances found in the MINC with more mechanistic data obtained in the assay itself, but also in other tests within the framework.
To sum up, the phenotype of the Cry2 knockout mice together with mechanistic data are in line with the finding in this report suggesting that CRY2 has a role in winter depression.
In general, when discussing our own mechanistic data obtained in mouse models we have changed to the wording "vascular leakage".
The mechanistic data presented in Figs. 3, 4 and 5 strongly suggest that the two-stage induction strategy increased membrane permeability, which caused increased extracellular α-CGTase production.
