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However, additional mechanistic data for HCO3−, related to the interactions of calcium (Ca2 +) precipitation at the microenvironment of the gill would dramatically increase the scientific knowledge base about how NaHCO3 might affect aquatic life.
In contrast, such mechanistic data for 'non-professional' phagocytic cells is scarce in the literature, and the process of phagosomal maturation in these cells is not well understood.
Since our detailed sequence analyses revealed that most NLRs and Apaf-1 share the same domain architecture and many secondary structure features, the availability of structural and mechanistic data for Apaf-1 provides the opportunity to link conserved sequence features of NLRs to functional aspects of NLR signaling.
The mechanistic data for both of these hypotheses should be at least mentioned here.
This model helps reconcile human, animal, and mechanistic data for soluble nickel compounds.
In vitro DNT data can reduce uncertainties in hazard prediction by providing mechanistic data for specific chemicals, including extrapolation between rodents and humans.
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For rat kidney carcinogenesis, mechanistic data informative for the evaluation of PCE's carcinogenic mode of action were identified (summarized in Table 2).
Moreover, armed by well understood fundamentals of single-site polymerization, researchers get more and more detailed mechanistic data, important for the improvement of the existing catalyst systems, and rational design of new effective catalysts.
Such hazard and risk assessments have to be continuously adapted to new toxicological findings; conventionally, these are observed toxic effects which are progressively supplemented with toxicokinetic and mechanistic data to allow for a more precise assessment of the extent and relevance of toxic effects on humans.
Secondly, this study provides mechanistic data supporting a role for MHC isoform switching and altered calcium handling as a basis for the observed susceptibility to pump dysfunction in LCR rats.
Hence, we aimed to develop strategies for mechanistic data interpretation to obtain translational information from our experiments.
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