Sentence examples for mechanistic data and from inspiring English sources

There are currently scarce mechanistic data and very limited data on the effect of CAM therapies on clinical outcomes.

Their significance in anticancer therapy is supported by mechanistic data and preliminary in vivo studies.

A subgroup of experts in cancer mechanisms assesses the strength of the mechanistic data and whether the mechanisms of tumor formation in experimental animals can operate in humans.

Authoritative occupational exposure limits are derived from comprehensive assessments of toxicodynamics, toxicokinetics, mechanistic data, and the evaluation of the underlying experimental data (MAK 2015).

Our exploration of the hypothesized PPAR-α activation MOA highlights some of the critical challenges pertinent to the evaluation of mechanistic data and its use in decisions regarding the relative human sensitivity for biological effects observed in laboratory animals.

The lack of mode-of-action information and correlation with CYP metabolism for hepatic vacuolation is in contrast with the mechanistic data and internal metric used for cancer (discussed in further detail below).

Based on mechanistic data, IARC and NTP upgraded ethylene oxide (IARC 1994; NTP 2004) and 2,3,7,8-tetrachlorodibenzo 2,3,7,8-tetrachlorodibenzo7; NTP 2004) from "probable" or "reasonably anticipated" human carcinogens to "known human carcinogens".

This account is supported by a large body of hematotoxicity studies (in animals and humans); toxicokinetic, genotoxocity, and mechanistic data in animals, humans, and in vitro; and a large body of null epidemiology findings.

Consideration was given to an array of information ranging from epidemiological findings and experimental animal and mechanistic data to screens of toxicity and disease pathways using HTS and literature curation methodologies.

The ultimate goal is that experimental and mechanistic data can lend support and biological plausibility to the human epidemiological observations.

We additionally highlight examples of reusing the clinical and mechanistic data to gain novel insights and building reference datasets and tools to benefit the community.