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The energetic and mechanistic data obtained from electrochemical studies of oxygen reduction permit to discuss the mechanisms of these hydroxylations.
In like fashion, regulators and risk assessors can be better equipped to apply mechanistic data if the concepts underlying mechanistic research and the limitations that must be placed on interpretation of mechanistic data are understood.
The ultimate goal is that experimental and mechanistic data can lend support and biological plausibility to the human epidemiological observations.
The main reasons were demanding time and work schedules, problems with quantification of visual information, and lack of mechanistic data.
Classical default-based risk assessment is evolving into a science-based risk assessment process that more fully utilizes mechanistic data.
The mechanistic data presented in Figs. 3, 4 and 5 strongly suggest that the two-stage induction strategy increased membrane permeability, which caused increased extracellular α-CGTase production.
"The most appropriate and scientifically based evaluation of the cancers reported in humans and laboratory animals as well as supportive mechanistic data is that glyphosate is a probable human carcinogen," the report states.
Experiments promoting, attenuating or maintaining a pluripotent phenotype were considered when they reveal mechanistic data.
Glycosyltransferases constitute a growing family of enzymes for which structural and mechanistic data urges.
Next, the integrated expression and expression variability data were aligned with the mechanistic data covering major human chronic diseases.
This mechanism is consistent with previous mechanistic data demonstrating increased caspase activity in acute myelogenous leukemia cells [42].
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