Genes with high noise in a single environment tend also to have high variation across different environmental conditions (plasticity), due at least in part to mechanistic coupling at the promoter level [ 2, 11, 15- 18].
Synchronization of electron transfer with proton-pumping reactions is an important means to minimize the dissipation of redox free energy and to optimize the mechanistic coupling and, hence, the efficiency of energy transduction.
An alternative explanation is that a rearrangement of ND3 and ND1 subunits during D to A transition is required for formation of a mechanistic coupling link between the quinone reduction step and conformationally driven proton translocation via antiporter-like channels in the membrane.
Interestingly, we demonstrate that for dozens of Myc-responsive transcripts (both induced and repressed), protein translation is modulated in a coordinated manner to augment the effect exerted on their transcription, indicating a mechanistic coupling between the regulation of the transcriptional and translational layers of gene expression upon Myc activation.
Mechanistic coupling of reactions as suggested here can flatten energetic landscapes and diminish thermodynamic barriers and can be another role for enzymatic complexes common in nature and a useful tool for metabolic engineering.
Detailed structural analysis demonstrates a mechanistic coupling between the maturation of the 5′ end of the 17S rRNA and the assembly of the 30S head domain, and attributes a unique role of S5 in coordinating these two events.
Our data of slippage kinetics when death was blocked, and death kinetics when slippage was blocked (Fig. 2 and 3), argue against mechanistic coupling.
Further recent discoveries provide major advances in our understanding of the mechanistic coupling between COPII and COPI.
However, the mechanistic details of SMARCAD1 coupling to the DNA damage response and repair pathways remains unknown.
Yield calculations were based on process-based simulations of 11 agricultural crops in a mechanistic coupled plant growth and water-balance model (for reference, see [40]).
