Sentence examples for mechanistic context of from inspiring English sources

Mode of action of these candidates was further reasoned in the mechanistic context of models by chains of arguments.

The integrative analysis of high-resolution array CGH and microarray expression data is now frequently applied to investigations of the mechanistic context of genomic aberrations.

Our results provide a mechanistic context for the role of TSG101 in cell invasion as a multifaceted gene.

These observations may provide a mechanistic context to the known protective roles of PPARα/γ in kidney diseases, such as diabetic nephropathy, which is associated with proteinuria and compromised expression of megalin.

Those using TGx technologies rely on a variety of resources to provide biological and mechanistic context to the gene changes observed via the microarray experiment.

To provide mechanistic context for our current voltage data, we analyzed the X-ray structure of the triple mutant and conducted a series of molecular dynamics simulations.

A current challenge for cancer biologists is to investigate the emerging genomic data in a mechanistic context, establishing the relationship of specific mutations to tumor biology and informing on clinical parameters including aggressiveness, response to therapy, and potential for metastasis.

The collapsibility hypothesis provides an example of a mechanistic context wherein nonhierarchical models for the linear predictor can sometimes make sense.

Yet even this is perhaps too strong, given that some parts of a mechanism might become unstable when removed from their mechanistic context.

Interestingly, TIMP-1 inhibits excitotoxic cell death in neuronal cells in animal models, likely through the modulation of intracellular calcium levels, but specific mechanistic studies in context of human targets and HAD are lacking.

This paper considers the utility of statistical goodness of fit testing in the context of mechanistic models of carcinogenesis.