Instead, the results of this work provide a step toward dissection of this phenomenological connection into specific, mechanistic components, and suggest that the factor primarily responsible for the observed anticorrelation between expression level and ER is the intrinsic robustness of proteins to misfolding.
These mechanistic components and associated characteristic gene expression changes closely resemble those implicated in demethylation in migratory PGCs (including cMyc, a signature response in 2i) and in preimplantation embryos (Seisenberger et al., 2012; Hackett et al., 2013; Kagiwada et al., 2013; Piccolo et al., 2013; Grabole et al., 2013).
The cross-talk between apoptosis and autophage is complicated by the sharing regulatory and mechanistic components, such as p62/SQSTM1 (Jin et al, 2009) and Bcl-2 family proteins (Levine et al, 2008).
This research avenue will undoubtedly help us to reconstruct the mechanistic components of metabolic interaction and cell cell interaction within microbial ecosystems, and may help to predict certain emergent properties of these systems.
It is designed as a hybrid of both empirical and mechanistic components that can be used for (1) making forest management decisions (e.g. growth and yield prediction), (2) quantifying forest carbon budgets, and (3) assessing the effects of climate change in both the short and long term.
Modeling of co-benefits generally takes the basic approach shown in Figure 1, employing a wide variety of methods such as comparative risk assessment (Smith and Haigler 2008), complex mechanistic components (such as those describing building physics, e.g., Wilkinson et al. 2009); and macroeconomic, technological, and behavioral models (National Research Council 2010).
Along with syndecans, syntenin-1 and ALIX are key mechanistic components in the production of exosomes, influencing intraluminal budding into MVBs.
Comprehensive analysis of ECG parameters describing the influence of the autonomic nervous system, the role of myocardial substrate, and the contribution of myocardial vulnerability could and should be employed in air pollution studies, especially as those mechanistic components have been proven to contribute to increased cardiovascular morbidity and mortality in general.
Knowledge about the biological processes involved is invaluable and enables the development of mechanistic components into the models, but insight into the physiological variations is at times insufficient, justifying the choice of empirical functions.
Constitutive expression of the cytokinin responsive transcription factor CRF2 and application of exogenous cytokinins both increase the activity of PDV2, linking cell division and chloroplast division and implying that the PDV proteins are primary mechanistic components in determining the cell's chloroplast complement.
In particular, they sequentially added mechanistic components on the simple model one-by-one based on both literatures and discrepancies with experimental observation.
