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Today, the mechanistic component of Descartes's dualism can be seen as the distant forerunner of the study of genetic components of motivation, while his other view of rational choices can be regarded as a precursor of modern cognitive approaches to motivation.
This comprehensive analysis puts forth the epitope repertoire as a mechanistic component of the multi-faceted HIV-specific CTL response.
This indicates that the inhibition of ERCC1 is a key mechanistic component of the synergy between the two drugs.
Chromosomal instability has been established as the key mechanistic component of cancer development (Fearon and Vogelstein 1990).
This link is well demonstrated in critically ill patients in relation to skeletal muscle degradation [ 22- 24], which is the major mechanistic component of the muscle depletion seen.
As a similar (∼80%) and significant reduction of EGFR and mTOR occurred after combination therapy, it is most likely that this dual suppression is a key mechanistic component of the observed tumour suppression.
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Following our previous results, we assumed that gene sets of associated disorders potentially harbor novel mechanistic components of the disease of interest.
This research avenue will undoubtedly help us to reconstruct the mechanistic components of metabolic interaction and cell cell interaction within microbial ecosystems, and may help to predict certain emergent properties of these systems.
Given the recent appreciation for the biological importance of lncRNAs, it is now clear that, regardless of the research project or field, one needs to ask whether lncRNAs are essential mechanistic components of the biological process under consideration.
(b) Superoxide has been proposed as an essential mechanistic component (by one of us [22]) and demonstrated to exist in reaction milieu by many workers as a deleterious side-product [9].
Thus, our results suggest that 5-HT3 and 5-HT7 receptor antagonism and 5-HT1A receptor agonism may collectively contribute to the enhancement of both the coordination and synchronization of neuronal networks, and this is likely a functional mechanistic component in mediating the actions of vortioxetine in humans.
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