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None of these compounds show similarity to any of the agents from other mechanistic classes such as topoisomerase inhibitors, alkylating agents and DNA/RNA antimetabolites (data not shown).
Autoimmune disorders are linked to different mechanistic classes such as fibrinolytic and antineoplastic agents as well as protease, kinase, and cycloxygenease inhibitors.
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Dehalogenases comprise a diverse group of enzymes belonging to different phylogenetic and mechanistic classes.
To confirm the ability of this model to stratify drugs based on mechanistic of action, future studies should be undertaken with drugs from additional mechanistic classes.
COMPARE computations for all of the potent compounds against standard anticancer agents from various mechanistic classes are performed.
With the exception of recombinant blood products, SPC changes were required for products belonging to all mechanistic classes.
BLs can be divided into two mechanistic classes – the serine-BLs (SBLs) and the metallo-BLs (MBLs).
Inverting glycoside hydrolases are arguably the simplest mechanistic class of enzymes that cleave the glycosidic linkage.
Molpher is an open-source software framework for the design of virtual chemical libraries focused on a particular mechanistic class of compounds.
In fact, antimitotic agents are the only mechanistic class showing consistent non-negligible positive correlation with take-rate.
A third mechanistic class includes cationic amphiphiles, which have been isolated from multiple screens of FDA-approved drugs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com