However, subsequent investigations of this mutation in other cases of HAE type III have not yielded similar findings, and as of yet the underlying genetic and mechanistic cause of this condition is unknown.
The present study investigates the cytotoxic, anti-proliferative and apoptotic effect of Fe-SP on various human neuroblastoma (NB) cell lines and defines the excessive generation of ROS as the underlying mechanistic cause of the drugs anti-cancer activity in NB as well as in OC cells.
The major mechanistic cause of substrate-wide loss of OCT1 activity is improper membrane localization.
A limitation in the use of [C]HED biodistribution to define sympathetic nervous system defects is the inability to delineate the mechanistic cause of the abnormality.
The mechanistic cause of aging perhaps cannot be found in merely monitoring the fluxes of resources within the organism; even if all resources are found to be allocated to maintenance, the organism may still age.
However, the exact mechanistic cause of the TP modulation by the cytotoxics has not been clearly elucidated and indirect effects via the upregulation of TNF α have been advocated (Sawada et al, 1998, 1999).
