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We can only speculate about the mechanistic background of these observations: As ADM has an in vivo half-life of only 22 min [30], a relatively short increase of ADM levels, especially in the early phase of sepsis progression, might be beneficial.
However, information about the mechanistic background of these trade-offs is largely lacking.
In this study, we investigated the mechanistic background of five AT1R receptor mutants previously published to be biased towards G protein-independent pathways.
While the mechanistic background of the fructose distribution in CSF vs. blood is unknown, it has been suggested that fructose is an end product of brain metabolism, accounting for the CSF plasma fructose ratio greater than unity.
These findings not only shed light on the mechanistic background of the biological effects caused by these drugs, but also show that cytarabine and decitabine might be useful in directly targeting the stem cell fraction of human tumours.
A set of genes is identified on a common mechanistic background of At. ferrooxidans and At.
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More reductionist models may be better suited to identify the mechanistic background for our observation of direct cardioprotection [ 15].
This study provides a sound mechanistic background for the medicinal application of Gentiana floribunda in hypertension.
The mechanistic background for these predictions comes from a qualitative consideration of the mechanical stability of a funnel-like membrane neck, an unavoidable intermediate stage of the fission process.
These findings could give a mechanistic background to the ongoing clinical studies being carried out based on empirical NAC treatment of patients having psoriasis.
Both of these frequent polymorphisms were demonstrated to strongly affect FCER1A expression in mast cells and/or basophils in an additive manner [17], [21], [22], thus providing a partial mechanistic background for the genetic associations described above.
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