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In this paper, a previously published phenomenological model with a valid mechanistic background is further elaborated and embedded in a vehicle simulation software (ADVISOR).
We can only speculate about the mechanistic background of these observations: As ADM has an in vivo half-life of only 22 min [30], a relatively short increase of ADM levels, especially in the early phase of sepsis progression, might be beneficial.
However, information about the mechanistic background of these trade-offs is largely lacking.
Depot-specific differences in response to testosterone pose an attractive mechanistic background for the observed differences in lipogenic activity during basal conditions.
In this study, we investigated the mechanistic background of five AT1R receptor mutants previously published to be biased towards G protein-independent pathways.
While the mechanistic background of the fructose distribution in CSF vs. blood is unknown, it has been suggested that fructose is an end product of brain metabolism, accounting for the CSF plasma fructose ratio greater than unity.
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Mechanistic backgrounds for an increased sensitivity to environmental pollutants in older adults. .
Mechanistic backgrounds for an increased sensitivity to environmental pollutants in older adults.
It has been shown that different symptoms or symptom combinations of neuropathic pain (NeP) may correspond to different mechanistic backgrounds and respond differently to treatment.
If you come in with a strong background in mechanistic science, molecular biology, and exposure to mammalian biology, that's a great substrate for us to work from".
Given this background, a mechanistic link between metabolic abnormalities and adverse renal and cardiovascular events seems likely.
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