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The reactions of professors and medical doctors in the one-week course were similar, but with an important novelty: they were deeply struck by the existence of evolutionary explanations for many structures and processes that they had only previously considered from the proximate, mechanistic angle.
An extension of this mechanistic angle should implicate which cell types are responsible for the suppression of tumorigenesis.
From a mechanistic angle, we show that ectopically expressed HDAC7 localizes to the nucleus and interacts with the transcription factor myocyte enhancer factor C (MEF2C) and the corepressors HDAC3 and SMRT.
From a mechanistic angle, the association between GC resistance and mutated IGVH genes is intriguing and may provide clues as to why upregulated Bim/Bcl-2 complexes fail to induce Bax/Bak activation and apoptosis in some samples.
Similar(8)
The divergence angle could arise from mechanistic constraints and be functionally useful (and thus limit selection for overcoming constraints to increased precision).
While past studies have suggested methods to improve location accuracy, mechanistic movement models utilize distributions of turning angles and directional biases and these data present a new challenge in recognizing and reducing the effect of measurement error.
Persistence, or dynamic changes in contact angle, are however, difficult to directly measure and incorporate into mechanistic conceptual and numerical models.
By calculating the time series of the Cα torsion angles and their clustering it is possible to determine the mechanistic details on a residual length scale and find major events occurring in the simulation of large proteins or protein complexes.
Besides the subsequent recent history of a more mechanistic elucidation of cell death, the authors also discuss cell death from an evolutionary angle and consider the therapeutic implications of many decades of research in this area.
Using polarization microscopy and low-angle X-ray diffraction, experimental evidence is provided to support a mechanistic model for the in cubo crystallization of bacteriorhodopsin in a lipid matrix.
For parameterization of mechanistic movement models, the objective is to accurately determine the distribution of turning angles, directional biases or step lengths and not necessarily to accurately resurrect the animal's true location, movement path or home range.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com