As mechanistic explanation, alternative models were presented: interaction of formaldehyde with human haematopoietic stem cells circulating in the blood and/or interaction of formaldehyde with primitive pluripotent stem cells in nasal/oral passages.
In order to facilitate subsequent mechanistic studies, we decided to use an alternative model, in which activated CD4+ T lymphocytes were transduced with lentiviral vectors carrying effector sequences, and analyzed for HIV1 permissiveness once back to a resting and restrictive state.
Validation of any alternative model is best achieved by sufficient mechanistic understanding of the model to reasonably predict the outcome of bioassays conducted in the models and use all available information on the drug or chemical.
No alternative model works".
An alternative model exists already.
Switzerland provides an alternative model.
Collins is rallying behind an alternative model.
An Alternative Model for MD/PhD Training.
The alternative model is the 'regulatory model'.
In conclusion, results suggest a mechanistic alternative to the fumarate-dependent reaction for anaerobic alkane activation.
