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However, the molecular mechanisms which mediate these effects of early-life CLI treatment on adult animals remain largely unknown.
Cranial autonomic symptoms, and activation of the cranial autonomic projection, are thought to modulate or even trigger activation of dural neuro-inflammatory mechanisms, which mediate dural trigeminovascular activation resulting in headache in primary headache.
As pediatric populations are particularly susceptible to malaria, it is important to investigate humoral and cellular immune responses in a younger age group to provide a better understanding of the immune mechanisms which mediate protection following RTS,S vaccination.
Since pediatric populations in endemic areas constitute the main target group for a malaria vaccine, it is important to investigate immune responses induced by RTS,S vaccines in this age group and also provide a better understanding of immune mechanisms which mediate protection.
Our finding of strong LD in a study population from West Africa between variants at position +6230 and the SNP located in the promoter region of CTLA4 (−1577) may open new avenues in the search for mechanisms which mediate the immunomodulatory effect of the +6230 variant.
Less is known about the potential mechanisms which mediate these associations.
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The existence of a mechanism which mediates the relationship between AA and BS is stated.
There is, however, no agreement about the dominating mechanism which mediates structural mobility at the microscale.
With regard to the mechanism which mediates expansion or contraction in the SVA VNTR region, Ostertag and colleagues [ 9] discussed "unequal homologous recombination" but cited Levinson (slipped-strand mispairing - SSM - [ 29]).
We hypothesized that promoter hypermethylation of HOXA4 could be an epigenetic mechanism which mediate resistance to IM in CML patients.
In contrast to mammals, in Drosophila only few studies tried to elucidate physiological functions of Sir2 and the molecular mechanisms, which may mediate its effect on life span.
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