Studies have supported that FOXP3 protein also has different roles, acting as a tumor suppressor protein [21], or as evading mechanisms for tumors, when expressed by Tregs [44].
Zingaro et al. identified several tolerance mechanisms from Lactobacillus plantarum, that when expressed in E. coli show improved survival and growth under ethanol stress [ 29].
7 8 Interestingly, H pylori cagA was shown to induce an EMT-like effect when expressed in epithelial cells, although the mechanism was not clarified.
ddTpp1 and human TPP1 localize to the lysosome when expressed in Dictyostelium, indicating conserved lysosomal function and trafficking mechanisms.
The ability to use genome data to clone and sequence genes which when expressed will provide antigens for vaccine screening and receptors and enzymes for mechanism-based chemotherapy screening will increase our options for parasite control.
When expressed in C. albicans HsRac1 also accumulates in the nucleus, suggesting that the mechanism of Rac1 nuclear import and retention is conserved from yeast to human.
It was found that GAP-43 is deacylated in vivo when expressed in Chinese hamster ovary (CHO -K1 and human HeLa CHO -K1hrough andechumanm mediated by APT-2, but not by APT-1.
However, the evolution of genes that, when expressed, produce proteins whose functions are incompatible with growth would require the parallel evolution of mechanisms for ensuring that these genes are not expressed in unstressed cycling cells.
When expressed alone in primary cells however, oncogenic Ras induces premature senescence, a putative tumour suppressor mechanism to protect from uncontrolled proliferation [18].
Interestingly, SNI1 also repressed transcription when expressed in yeast, suggesting that it functions as an active transcriptional repressor through a highly conserved mechanism.
