Like Mario Kart DS, it includes on-line play; it also allows racers to play as user-created Miis (after unlocking the Mii character) as well as Mario series characters and comes packaged with the Wii Wheel peripheral, which can act as the game's primary control mechanism when coupled with a Wii Remote.
In addition, the role of persistent infection in organs of infected birds cannot be excluded, which may represent a further infection overwintering mechanism when coupled with the predation by other bird species, as, for example, those belonging to Corvidae or Falconidae families [ 91].
Mathematical models play an important role in identifying these mechanisms and, when coupled with empirical work, can determine whether or not a given mechanism is operating in a specific population or community.
Increased atrial myofibroblast density could promote AF via multiple arrhythmia mechanisms since, when coupled to cardiomyocytes, myofibroblasts can act as current sources and/or sinks, depending on myofibroblast density, distribution, and coupling strength, thereby modulating AP characteristics and CV, including production of SDs and alternans.
The reduced mechanism inherits the major reaction pathways of the detailed mechanism, which ensures its predictive capability when coupled into CFD simulations.
Such restriction of the virus yield could be particularly useful when coupled with "delayed action" defense mechanisms, such as the Pgl system.
Natural mechanisms of duplication, co-option, and divergence of components, when coupled with natural selection, are amazingly creative and powerful.
We also know that clear national road safety strategies containing goals and targets have proven successful in many countries around the world, when coupled with information campaigns to mobilize civil society and strengthened enforcement mechanisms.
When coupled with additional biological knowledge, they can also be helpful for deciphering biological mechanisms responsible for disease.
